TY - JOUR
T1 - Cardiorespiratory fitness and incident lung and colorectal cancer in men and women
T2 - Results from the Henry Ford Exercise Testing (FIT) cohort
AU - Marshall, Catherine Handy
AU - Al-Mallah, Mouaz H.
AU - Dardari, Zeina
AU - Brawner, Clinton A.
AU - Lamerato, Lois E.
AU - Keteyian, Steven J.
AU - Ehrman, Jonathan K.
AU - Visvanathan, Kala
AU - Blaha, Michael J.
N1 - Funding Information:
Catherine Handy Marshall has received a grant from the Conquer Cancer Foundation from Bristol Myers-Squibb for work performed as part of the current study and has acted as a paid consultant for McGraw-Hill and received travel fees from Dava Oncology for work performed outside of the current study. Lois E. Lamerato has received funding from AstraZeneca, Pfizer, Merck, Policy Analysis Incorporated, the National Cancer Institute, Xcenda, and eMaxHealth for work performed outside of the current study. Michael Blaha has received grants from the National Institutes of Health; grants and personal fees from the US Food and Drug Administration; grants from the American Heart Association and Aetna Foundation; grants and personal fees from Amgen Foundation; and personal fees from Novartis, Sanofi, Regeneron, MedImmune, Akcea Therapeutics, Medicure, and Novo Nordisk for work performed outside of the current study. The other authors made no disclosures. Supported by the Conquer Cancer Foundation Young Investigator Award (to Catherine Handy Marshall).
Funding Information:
Supported by the Conquer Cancer Foundation Young Investigator Award (to Catherine Handy Marshall).
Publisher Copyright:
© 2019 American Cancer Society
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Background: To the authors’ knowledge, the relationship between cardiorespiratory fitness (CRF) and lung and colorectal cancer outcomes is not well established. Methods: A retrospective cohort study was performed of 49,143 consecutive patients who underwent clinician-referred exercise stress testing from 1991 through 2009. The patients ranged in age from 40 to 70 years, were without cancer, and were treated within the Henry Ford Health System in Detroit, Michigan. CRF, measured in metabolic equivalents of task (METs), was categorized as <6 (reference), 6 to 9, 10 to 11, and ≥12. Incident cancer was obtained through linkage to the cancer registry and all-cause mortality from the National Death Index. Results: Participants had a mean age of 54 ± 8 years. Approximately 46% were female, 64% were white, 29% were black, and 1% were Hispanic. The median follow-up was 7.7 years. Cox proportional hazard models, adjusted for age, race, sex, body mass index, smoking history, and diabetes, found that those in the highest fitness category (METs ≥12) had a 77% decreased risk of lung cancer (hazard ratio [HR], 0.23; 95% CI, 0.14-0.36) and a 61% decreased risk of incident colorectal cancer (HR, 0.39; 95% CI, 0.23-0.66; with additional adjustment for aspirin and statin use). Among those diagnosed with lung and colorectal cancer, those with high fitness had a decreased risk of subsequent death of 44% and 89%, respectively (HR, 0.56 [95% CI, 0.32-1.00] and HR, 0.11 [95% CI, 0.03-0.37], respectively). Conclusions: In what to the authors’ knowledge is the largest study performed to date, higher CRF was associated with a lower risk of incident lung and colorectal cancer in men and women and a lower risk of all-cause mortality among those diagnosed with lung or colorectal cancer.
AB - Background: To the authors’ knowledge, the relationship between cardiorespiratory fitness (CRF) and lung and colorectal cancer outcomes is not well established. Methods: A retrospective cohort study was performed of 49,143 consecutive patients who underwent clinician-referred exercise stress testing from 1991 through 2009. The patients ranged in age from 40 to 70 years, were without cancer, and were treated within the Henry Ford Health System in Detroit, Michigan. CRF, measured in metabolic equivalents of task (METs), was categorized as <6 (reference), 6 to 9, 10 to 11, and ≥12. Incident cancer was obtained through linkage to the cancer registry and all-cause mortality from the National Death Index. Results: Participants had a mean age of 54 ± 8 years. Approximately 46% were female, 64% were white, 29% were black, and 1% were Hispanic. The median follow-up was 7.7 years. Cox proportional hazard models, adjusted for age, race, sex, body mass index, smoking history, and diabetes, found that those in the highest fitness category (METs ≥12) had a 77% decreased risk of lung cancer (hazard ratio [HR], 0.23; 95% CI, 0.14-0.36) and a 61% decreased risk of incident colorectal cancer (HR, 0.39; 95% CI, 0.23-0.66; with additional adjustment for aspirin and statin use). Among those diagnosed with lung and colorectal cancer, those with high fitness had a decreased risk of subsequent death of 44% and 89%, respectively (HR, 0.56 [95% CI, 0.32-1.00] and HR, 0.11 [95% CI, 0.03-0.37], respectively). Conclusions: In what to the authors’ knowledge is the largest study performed to date, higher CRF was associated with a lower risk of incident lung and colorectal cancer in men and women and a lower risk of all-cause mortality among those diagnosed with lung or colorectal cancer.
KW - cancer risk
KW - cardiorespiratory fitness
KW - colorectal cancer
KW - lung cancer
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U2 - 10.1002/cncr.32085
DO - 10.1002/cncr.32085
M3 - Article
C2 - 31056756
AN - SCOPUS:85065316030
VL - 125
SP - 2594
EP - 2601
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 15
ER -