Cardiac hypertrophy simulations using parametric and echocardiography-based left ventricle model with shell finite elements

Bogdan Milićević, Miljan Milošević, Vladimir Simić, Danijela Trifunović, Goran Stanković, Nenad Filipović, Miloš Kojić

Research output: Contribution to journalArticlepeer-review


In our paper, we simulated cardiac hypertrophy with the use of shell elements in parametric and echocardiography-based left ventricle (LV) models. The hypertrophy has an impact on the change in the wall thickness, displacement field and the overall functioning of the heart. We computed both eccentric and concentric hypertrophy effects and tracked changes in the ventricle shape and wall thickness. Thickening of the wall was developed under the influence of concentric hypertrophy, while the eccentric hypertrophy produces wall thinning. To model passive stresses we used the recently developed material modal based on the Holzapfel experiments. Also, our specific shell composite finite element models for heart mechanics are much smaller and simpler to use with respect to conventional 3D models. Furthermore, the presented modeling approach of the echocardiography-based LV can serve as the basis for practical applications since it relies on the true patient-specific geometry and experimental constitutive relationships. Our model gives an insight into hypertrophy development in realistic heart geometries, and it has the potential to test medical hypotheses regarding hypertrophy evolution in a healthy and heart with a disease, under the influence of different conditions and parameters.

Original languageEnglish (US)
Article number106742
Pages (from-to)106742
JournalComputers in Biology and Medicine
StatePublished - May 2023


  • Humans
  • Heart Ventricles/diagnostic imaging
  • Hypertrophy, Left Ventricular/diagnostic imaging
  • Echocardiography
  • Cardiomegaly/diagnostic imaging
  • Heart
  • Hypertension

ASJC Scopus subject areas

  • Health Informatics
  • Computer Science Applications


Dive into the research topics of 'Cardiac hypertrophy simulations using parametric and echocardiography-based left ventricle model with shell finite elements'. Together they form a unique fingerprint.

Cite this