Carboxyl-functionalized superparamagnetic Fe 3O 4/Poly(St-co-MPS)/SiO 2 composite particles for rapid and sensitive immunoassay

Hang Yuan, Feng Yan, Lan Ma, Feng Wu, Jiaqi Zhuang, Wensheng Yang

Research output: Contribution to journalArticle

10 Scopus citations


Superparamagnetic Fe 3O 4/poly(St-co-MPS)/SiO 2 composite particles with the average size of 140 nm were functionalized with carboxyl group by emulsion polymerization. Functionalized particles with carboxyl contents of 13.6 and 136 μmol/mL were prepared by changing the amount of acrylic acid monomer used in the polymerization. After conjugation with human chorionic gonadotrophin (hCG) antibody, the particles were used to construct lateral flow immunoassays (LFIA) for the detection of hCG in solution. The quantitative analysis could be finished in 20 min by using the magnetic particles as labels. The detection limit of LFIA was determined to be 1 and 5 IU/L respectively for the magnetic particles with carboxyl contents of 13.6 and 136 μmol/mL.

Original languageEnglish (US)
Pages (from-to)2232-2236
Number of pages5
JournalJournal of Nanoscience and Nanotechnology
Issue number3
StatePublished - Mar 2011


  • Carboxyl group
  • Lateral flow immunoassay
  • Sensitivity
  • Superparamagnetic particles

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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