[carbonyl-11C]Benzyl acetate: Automated radiosynthesis via Pd-mediated [11C]carbon monoxide chemistry and PET measurement of brain uptake in monkey

Shuiyu Lu, Jinsoo Hong, Tetsuji Itoh, Masahiro Fujita, Osamu Inoue, Robert B. Innis, Victor W. Pikea

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

[carbonyl-11C]Benzyl acetate ([11C]1) has been proposed as a potential agent for imaging glial metabolism of acetate to glutamate and glutamine with positron emission tomography. [11C]1 was synthesized from [11C]carbon monoxide, iodomethane and benzyl alcohol via palladium-mediated chemistry. The radiosynthesis was automated with a modified Synthia platform controlled with in-house developed Labview software. Under production conditions, [11C]1 was obtained in 10% (n = 6) decay-corrected radiochemical yield from [11C]carbon monoxide in >96% radiochemical purity and with an average specific radioactivity of 2415 mCi/μmol. The total radiosynthesis time was about 45 min. Peak uptake of radioactivity in monkey brain (SUV = 3.1) was relatively high and may be amenable to measuring uptake and metabolism of acetate in glial cells of the brain.

Original languageEnglish (US)
Pages (from-to)548-551
Number of pages4
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume53
Issue number8
DOIs
StatePublished - Jun 30 2010

Keywords

  • Carbon-11
  • Carbonylation
  • PET
  • [C]benzyl acetate
  • [C]carbon monoxide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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