Carbonated-apatite/gelatine porous scaffolds for bone replacement

Elena Landi, Seianna Martorana, Anna Tampieri, Stefano Guicciardi, Cesare Melandri

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A novel foaming method of design and synthesis of porous Carbonate-apatite/gelatine composite scaffolds is proposed for biomedical applications. Two different suspensions, one constituted by a biomimetic inorganic phase (B-CHA) and the second by a protein (gelatine), are mixed, foamed, lyophilized and, in some cases, cross-linked to stabilize the organic phase. Chemical, morphological and mechanical features of the scaffolds are evaluated. The samples have chemical composition, compressive and flexural strengths and Young modulus values in the range of trabecular bone ones. A high interconnected porosity (about 90%) showing a micro- to macrosize distribution, that is needed for osteoconduction and vascolarization processes in vivo, is also detected.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
StatePublished - 2008

Keywords

  • Biohybrid composites
  • Carbonated-hydroxyapatite
  • Gelatine
  • Porous scaffolds

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

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