Carbonate hydroxyapatite functionalization: A comparative study towards (bio)molecules fixation

Laura Russo; Francesca Taraballi; Cristina Lupo; Ana Poveda; Jesús Jiménez-Barbero; Monica Sandri; Anna Tampieri; Francesco Nicotra; Laura Cipolla

doi:10.1098/rsfs.2013.0040

Carbonate hydroxyapatite functionalization: A comparative study towards (bio)molecules fixation

Laura Russo, Francesca Taraballi, Cristina Lupo, Ana Poveda, Jesús Jiménez-Barbero, Monica Sandri, Anna Tampieri, Francesco Nicotra, Laura Cipolla

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Abstract

Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting.

Original language	English (US)
Article number	20130040
Journal	Interface Focus
Volume	4
Issue number	1
DOIs	https://doi.org/10.1098/rsfs.2013.0040
State	Published - Feb 6 2014

Keywords

APTES
Bioceramics
Carbonate hydroxyapatite
Covalent functionalization
NMR
Sol-gel

ASJC Scopus subject areas

Biophysics
Biotechnology
Biochemistry
Bioengineering
Biomedical Engineering
Biomaterials

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10.1098/rsfs.2013.0040

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abstract = "Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting.",

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AU - Taraballi, Francesca

AU - Lupo, Cristina

AU - Poveda, Ana

AU - Jiménez-Barbero, Jesús

AU - Sandri, Monica

AU - Tampieri, Anna

AU - Nicotra, Francesco

AU - Cipolla, Laura

PY - 2014/2/6

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AB - Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting.

KW - APTES

KW - Bioceramics

KW - Carbonate hydroxyapatite

KW - Covalent functionalization

KW - NMR

KW - Sol-gel

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Carbonate hydroxyapatite functionalization: A comparative study towards (bio)molecules fixation

Abstract

Keywords

ASJC Scopus subject areas

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