Carbonate hydroxyapatite functionalization: A comparative study towards (bio)molecules fixation

Laura Russo, Francesca Taraballi, Cristina Lupo, Ana Poveda, Jesús Jiménez-Barbero, Monica Sandri, Anna Tampieri, Francesco Nicotra, Laura Cipolla

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting.

Original languageEnglish (US)
Article number20130040
JournalInterface Focus
Issue number1
StatePublished - Feb 6 2014


  • Bioceramics
  • Carbonate hydroxyapatite
  • Covalent functionalization
  • NMR
  • Sol-gel

ASJC Scopus subject areas

  • Biophysics
  • Biotechnology
  • Biochemistry
  • Bioengineering
  • Biomedical Engineering
  • Biomaterials


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