Carbon nanotubes assisted biomimetic synthesis of hydroxyapatite from simulated body fluid

Santosh Aryal, Shanta Raj Bhattarai, Remant Bahadur Remant, Myung Seob Khil, Duck Rae Lee, Hak Yong Kim

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Synthesis of hydroxyapatite (HA) using carboxylated carbon nanotubes were investigated using simulated body fluid (SBF) similar to physiological condition and products tailored to have chemistry found to mimic natural bone. Composites were synthesized under ambient condition and physiological temperature (37 °C). Former results the formation of dense net over carbon nanotubes even after 21 days of reaction, a hierarchy assemblies, whereas later results the formation of large crystals after 7 days of reaction. Physico-chemical characterization of composite material showed that the nucleation of HA initiates through the carboxyl group. Different parameters like temperature and reaction time were found to control the crystallization of HA. After 7 days of reaction, the crystal becames denser and directs towards the single plane; (0 0 2), thereby showing its phase purity. The result showed that the carboxylated carbon nanotubes were capable to nucleate HA from SBF, which can be used as a biomaterial for the modification of implant materials.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalMaterials Science and Engineering A
Issue number1-2
StatePublished - Jun 25 2006


  • Biomaterials
  • Biomimetic
  • Biomineralization
  • Carbon nanotubes
  • Hydroxyapatite

ASJC Scopus subject areas

  • Materials Science(all)


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