Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta Raj Bhattarai; Santosh Aryal; Remant Bahadur K.C.; Narayan Bhattarai; Pyong Han Hwang; Ho Keun Yi; Hak Yong Kim

doi:10.1016/j.msec.2006.11.008

Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta Raj Bhattarai, Santosh Aryal, Remant Bahadur K.C., Narayan Bhattarai, Pyong Han Hwang, Ho Keun Yi, Hak Yong Kim

Houston Methodist

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system.

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Materials Science and Engineering C
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.msec.2006.11.008
State	Published - Jan 10 2008

Keywords

Biomaterials
Calcium compounds
Carbon nanotubes
Nanomaterials, DNA

ASJC Scopus subject areas

Biomaterials

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10.1016/j.msec.2006.11.008

Cite this

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title = "Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation",

abstract = "This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system.",

keywords = "Biomaterials, Calcium compounds, Carbon nanotubes, Nanomaterials, DNA",

author = "Bhattarai, {Shanta Raj} and Santosh Aryal and {Bahadur K.C.}, Remant and Narayan Bhattarai and {Han Hwang}, Pyong and {Keun Yi}, Ho and {Yong Kim}, Hak",

note = "Funding Information: This research was supported by the Korean Ministry of Education and Human Resource Development through the Center for Healthcare Technology Development, Chonbuk National University, Jeonju 561–756, Republic of Korea.",

year = "2008",

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doi = "10.1016/j.msec.2006.11.008",

language = "English (US)",

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journal = "Materials Science and Engineering C",

issn = "0928-4931",

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TY - JOUR

T1 - Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

AU - Bhattarai, Shanta Raj

AU - Aryal, Santosh

AU - Bahadur K.C., Remant

AU - Bhattarai, Narayan

AU - Han Hwang, Pyong

AU - Keun Yi, Ho

AU - Yong Kim, Hak

N1 - Funding Information: This research was supported by the Korean Ministry of Education and Human Resource Development through the Center for Healthcare Technology Development, Chonbuk National University, Jeonju 561–756, Republic of Korea.

PY - 2008/1/10

Y1 - 2008/1/10

N2 - This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system.

AB - This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system.

KW - Biomaterials

KW - Calcium compounds

KW - Carbon nanotubes

KW - Nanomaterials, DNA

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DO - 10.1016/j.msec.2006.11.008

M3 - Article

AN - SCOPUS:37349122749

SN - 0928-4931

VL - 28

SP - 64

EP - 69

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 1

ER -

Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Abstract

Keywords

ASJC Scopus subject areas

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