Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta Raj Bhattarai, Santosh Aryal, Remant Bahadur K.C., Narayan Bhattarai, Pyong Han Hwang, Ho Keun Yi, Hak Yong Kim

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalMaterials Science and Engineering C
Volume28
Issue number1
DOIs
StatePublished - Jan 10 2008

Keywords

  • Biomaterials
  • Calcium compounds
  • Carbon nanotubes
  • Nanomaterials, DNA

ASJC Scopus subject areas

  • Biomaterials

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