Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

Laura Russo; Alfonso Gautieri; Mario Raspanti; Francesca Taraballi; Francesco Nicotra; Simone Vesentini; Laura Cipolla

doi:10.1016/j.carres.2013.11.008

Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

Laura Russo, Alfonso Gautieri, Mario Raspanti, Francesca Taraballi, Francesco Nicotra, Simone Vesentini, Laura Cipolla

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

Original language	English (US)
Pages (from-to)	12-7
Number of pages	6
Journal	Carbohydrate Research
Volume	389
DOIs	https://doi.org/10.1016/j.carres.2013.11.008
State	Published - May 7 2014

Keywords

Animals
Biocompatible Materials
Carbohydrate Conformation
Collagen
Drug Design
Glycosylation
Lactose
Molecular Dynamics Simulation
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.carres.2013.11.008

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title = "Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial",

abstract = "Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.",

keywords = "Animals, Biocompatible Materials, Carbohydrate Conformation, Collagen, Drug Design, Glycosylation, Lactose, Molecular Dynamics Simulation, Journal Article, Research Support, Non-U.S. Gov't",

author = "Laura Russo and Alfonso Gautieri and Mario Raspanti and Francesca Taraballi and Francesco Nicotra and Simone Vesentini and Laura Cipolla",

year = "2014",

month = may,

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doi = "10.1016/j.carres.2013.11.008",

language = "English (US)",

volume = "389",

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journal = "Carbohydrate Research",

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T1 - Carbohydrate-functionalized collagen matrices

T2 - design and characterization of a novel neoglycosylated biomaterial

AU - Russo, Laura

AU - Gautieri, Alfonso

AU - Raspanti, Mario

AU - Taraballi, Francesca

AU - Nicotra, Francesco

AU - Vesentini, Simone

AU - Cipolla, Laura

PY - 2014/5/7

Y1 - 2014/5/7

N2 - Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

AB - Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

KW - Animals

KW - Biocompatible Materials

KW - Carbohydrate Conformation

KW - Collagen

KW - Drug Design

KW - Glycosylation

KW - Lactose

KW - Molecular Dynamics Simulation

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.carres.2013.11.008

DO - 10.1016/j.carres.2013.11.008

M3 - Article

C2 - 24332940

SN - 0008-6215

VL - 389

SP - 12

EP - 17

JO - Carbohydrate Research

JF - Carbohydrate Research

ER -

Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

Abstract

Keywords

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