Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial

Laura Russo, Alfonso Gautieri, Mario Raspanti, Francesca Taraballi, Francesco Nicotra, Simone Vesentini, Laura Cipolla

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Collagen matrices have been neoglycosylated with lactose by reductive amination at lysine side chains. AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition.

Original languageEnglish (US)
Pages (from-to)12-7
Number of pages6
JournalCarbohydrate Research
Volume389
DOIs
StatePublished - May 7 2014

Keywords

  • Animals
  • Biocompatible Materials
  • Carbohydrate Conformation
  • Collagen
  • Drug Design
  • Glycosylation
  • Lactose
  • Molecular Dynamics Simulation
  • Journal Article
  • Research Support, Non-U.S. Gov't

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