CAR-T cell therapy for lymphoma

Carlos A. Ramos, Helen Heslop, Malcolm Brenner

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Lymphomas arise from clonal expansions of B, T, or NK cells at different stages of differentiation. Because they occur in the immunocyte-rich lymphoid tissues, they are easily accessible to antibodies and cell-based immunotherapy. Expressing chimeric antigen receptors (CARs) on T cells is a means of combining the antigen-binding site of a monoclonal antibody with the activating machinery of a T cell, enabling antigen recognition independent of major histocompatibility complex restriction, while retaining the desirable antitumor properties of a T cell. Here, we discuss the basic design of CARs and their potential advantages and disadvantages over other immune therapies for lymphomas. We review current clinical trials in the field and consider strategies to improve the in vivo function and safety of immune cells expressing CARs. The ultimate driver of CAR development and implementation for lymphoma will be the demonstration of their ability to safely and cost-effectively cure these malignancies.

Original languageEnglish (US)
Pages (from-to)165-183
Number of pages19
JournalAnnual Review of Medicine
Volume67
DOIs
StatePublished - Jan 14 2016

Keywords

  • Adoptive T cell therapy
  • CD19
  • CD20
  • CD30
  • Immunotherapy
  • Kappa light chain

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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