Cancer Stem Cells and Immunosuppressive Microenvironment in Glioma

Qianquan Ma, Wenyong Long, Changsheng Xing, Junjun Chu, Mei Luo, Helen Yicheng Wang, Qing Liu, Rongfu Wang

Research output: Contribution to journalReview articlepeer-review

148 Scopus citations


Glioma is one of the most common malignant tumors of the central nervous system and is characterized by extensive infiltrative growth, neovascularization, and resistance to various combined therapies. In addition to heterogenous populations of tumor cells, the glioma stem cells (GSCs) and other nontumor cells present in the glioma microenvironment serve as critical regulators of tumor progression and recurrence. In this review, we discuss the role of several resident or peripheral factors with distinct tumor-promoting features and their dynamic interactions in the development of glioma. Localized antitumor factors could be silenced or even converted to suppressive phenotypes, due to stemness-related cell reprogramming and immunosuppressive mediators in glioma-derived microenvironment. Furthermore, we summarize the latest knowledge on GSCs and key microenvironment components, and discuss the emerging immunotherapeutic strategies to cure this disease.

Original languageEnglish (US)
Number of pages1
JournalFrontiers in immunology
StatePublished - Jan 1 2018


  • cancer stem cell
  • glioma
  • immunosuppression
  • immunotherapy
  • tumor microenvironment

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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