TY - JOUR
T1 - Cancer stem cells
T2 - A review of potential clinical applications
AU - Podberezin, Mark
AU - Wen, Jianguo
AU - Chang, Chung Che
PY - 2013/8
Y1 - 2013/8
N2 - Context.-Cancer stem cells (CSCs) comprise a minor cell population in a tumor; however, they possess selfrenewal capacity and are responsible for tumor recurrence and the emerging issue of tumor resistance. Despite recent advances in the study of pathogenesis and mechanisms of CSC-mediated disease recurrence and multidrug resistance, many questions remain unanswered. Objectives.-To provide an overview of CSC theory and to describe major methods of CSC detection and isolation, with the emphasis on those techniques that are potentially relevant in clinical laboratory practice. Particular attention is given to CSC markers, such as cancer testis antigens, which could become promising targets in the development of immunotherapy in settings of minimal residual disease. Data Sources.-The review is based on analysis of peerreviewed literature cited in PubMed, as well as preliminary results of studies conducted in our laboratory. Conclusions.-Despite a lack of consensus in the scientific community on research methodology, CSCs have demonstrated significant potential as therapeutic targets in the treatment of cancer. Further research of CSC biology and markers will eventually lead to the development of novel therapeutic approaches for targeting these cells to treat resistant and recurrent tumors and minimal residual disease.
AB - Context.-Cancer stem cells (CSCs) comprise a minor cell population in a tumor; however, they possess selfrenewal capacity and are responsible for tumor recurrence and the emerging issue of tumor resistance. Despite recent advances in the study of pathogenesis and mechanisms of CSC-mediated disease recurrence and multidrug resistance, many questions remain unanswered. Objectives.-To provide an overview of CSC theory and to describe major methods of CSC detection and isolation, with the emphasis on those techniques that are potentially relevant in clinical laboratory practice. Particular attention is given to CSC markers, such as cancer testis antigens, which could become promising targets in the development of immunotherapy in settings of minimal residual disease. Data Sources.-The review is based on analysis of peerreviewed literature cited in PubMed, as well as preliminary results of studies conducted in our laboratory. Conclusions.-Despite a lack of consensus in the scientific community on research methodology, CSCs have demonstrated significant potential as therapeutic targets in the treatment of cancer. Further research of CSC biology and markers will eventually lead to the development of novel therapeutic approaches for targeting these cells to treat resistant and recurrent tumors and minimal residual disease.
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U2 - 10.5858/arpa.2012-0494-RA
DO - 10.5858/arpa.2012-0494-RA
M3 - Review article
C2 - 23153183
AN - SCOPUS:84879422194
SN - 0003-9985
VL - 137
SP - 1111
EP - 1116
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 8
ER -