Abstract
The recent identification of a subpopulation of cancer cells with characteristics of somatic stem cells and tumor-initiating capacity [1-5] is causing a paradigm shift in the way we think about anti-cancer therapies. Growing evidence suggests cancer stem cells uniquely propagate many malignancies and are resistant to conventional therapies. Targeting these cells is essential for chronic and curative therapy. Here, we review the use of in vitro and in vivo models for cancer stem cell research.
Original language | English (US) |
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Pages (from-to) | 47-52 |
Number of pages | 6 |
Journal | Drug Discovery Today: Disease Models |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - 2007 |
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery