Cancer stem cells

Kyuson Yun; Barbara Tennent

doi:10.1016/j.ddmod.2007.10.001

Cancer stem cells

Kyuson Yun, Barbara Tennent

Research Institute

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The recent identification of a subpopulation of cancer cells with characteristics of somatic stem cells and tumor-initiating capacity [1-5] is causing a paradigm shift in the way we think about anti-cancer therapies. Growing evidence suggests cancer stem cells uniquely propagate many malignancies and are resistant to conventional therapies. Targeting these cells is essential for chronic and curative therapy. Here, we review the use of in vitro and in vivo models for cancer stem cell research.

Original language	English (US)
Pages (from-to)	47-52
Number of pages	6
Journal	Drug Discovery Today: Disease Models
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmod.2007.10.001
State	Published - 2007

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmod.2007.10.001

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title = "Cancer stem cells",

abstract = "The recent identification of a subpopulation of cancer cells with characteristics of somatic stem cells and tumor-initiating capacity [1-5] is causing a paradigm shift in the way we think about anti-cancer therapies. Growing evidence suggests cancer stem cells uniquely propagate many malignancies and are resistant to conventional therapies. Targeting these cells is essential for chronic and curative therapy. Here, we review the use of in vitro and in vivo models for cancer stem cell research.",

author = "Kyuson Yun and Barbara Tennent",

note = "Funding Information: We would like to thank Grace Stafford for providing the data base link information presented on Table 1 . This work was supported by CA034196 The Jackson Laboratory Cancer Center Support Grant funds to KY. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2007",

doi = "10.1016/j.ddmod.2007.10.001",

language = "English (US)",

volume = "4",

pages = "47--52",

journal = "Drug Discovery Today: Disease Models",

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T1 - Cancer stem cells

AU - Yun, Kyuson

AU - Tennent, Barbara

N1 - Funding Information: We would like to thank Grace Stafford for providing the data base link information presented on Table 1 . This work was supported by CA034196 The Jackson Laboratory Cancer Center Support Grant funds to KY. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2007

Y1 - 2007

N2 - The recent identification of a subpopulation of cancer cells with characteristics of somatic stem cells and tumor-initiating capacity [1-5] is causing a paradigm shift in the way we think about anti-cancer therapies. Growing evidence suggests cancer stem cells uniquely propagate many malignancies and are resistant to conventional therapies. Targeting these cells is essential for chronic and curative therapy. Here, we review the use of in vitro and in vivo models for cancer stem cell research.

AB - The recent identification of a subpopulation of cancer cells with characteristics of somatic stem cells and tumor-initiating capacity [1-5] is causing a paradigm shift in the way we think about anti-cancer therapies. Growing evidence suggests cancer stem cells uniquely propagate many malignancies and are resistant to conventional therapies. Targeting these cells is essential for chronic and curative therapy. Here, we review the use of in vitro and in vivo models for cancer stem cell research.

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DO - 10.1016/j.ddmod.2007.10.001

M3 - Review article

AN - SCOPUS:40849111641

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JO - Drug Discovery Today: Disease Models

JF - Drug Discovery Today: Disease Models

SN - 1740-6757

IS - 2

ER -

Cancer stem cells

Abstract

ASJC Scopus subject areas

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