Cancer dissemination: A consequence of limited carrying capacity?

Thomas S. Deisboeck, Zhihui Wang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Assuming that there is feedback between an expanding cancer system and its organ-typical microenvironment, we argue here that such local tumor growth is initially guided by co-existence rather than competition with the surrounding tissue. We then present a novel concept that understands cancer dissemination as a biological mechanism to evade the specific carrying capacity limit of its host organ. This conceptual framework allows us to relate the tumor system's volumetric growth rate to the host organ's functionality-conveying composite infrastructure, and, intriguingly, already provides useful insights into several clinical findings.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalMedical Hypotheses
Issue number1
StatePublished - May 8 2007

ASJC Scopus subject areas

  • Medicine(all)


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