Abstract
In the present paper the synthesis of β-TCP powder and the design of porous and dense ceramics blocks to be used as drug delivery system were examined. Powder and material preparation methodologies were carefully investigated: 5-fluorouracil (5-FU) was loaded on TCP porous and dense blocks and compacted powders using a vacuum adsorption technique and the addition of various organic fillers to modulate the release kinetic was performed. Our results show that the release can be modulated between 2 and 30 days depending on the different combinations of experimental variables (ceramic microstructure, organic additives, drug load, etc).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 901-904 |
| Number of pages | 4 |
| Journal | Key Engineering Materials |
| Volume | 192-195 |
| State | Published - Jan 1 2001 |
| Event | 13th international Symposium on Ceramics in Medicine (BIOCERAMICS) - Bologna, Italy Duration: Nov 22 2000 → Nov 26 2000 |
ASJC Scopus subject areas
- Materials Science(all)
- Mechanics of Materials
- Mechanical Engineering