Calcium as a possible modulator of Kupffer cell phagocytic function by regulating liver-specific opsonic activity

S. Moein Moghimi, Harish M. Patel

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21 Scopus citations


Recently we described some properties of organ-specific serum opsonins which differentiate between liver- and spleen-specific opsonic activities, and reported that, on dialysis of serum, its liver opsonic activity is enhanced by 2- to 3-fold, whereas spleen-specific activity is reduced by 20-30% of that of control serum (Moghimi, S.M. and Patel, H.M. (1989) Biochim. Biophys. Acta 984, 379-383). This observation suggests that serum contains dialysable factors which regulate liver- as well as spleen-specific opsonic activities. Our results from EGTA-treated serum suggest that dialysable factor(s) could be divalent cations such as Ca2+, Mn2+, Mg2+ or Co2+, and among them, calcium may be the key regulatory factor for liver-specific opsonic activity. The regulatory mechanism of spleen-specific opsonic activity seems to be complex, since addition of dialysate or calcium or magnesium to the dialysed serum does not restore its activity; probably the removal of divalent cations has induced an irreversible conformational change in spleen-specific opsonin. In conclusion, we propose that the blood calcium concentration may play an important role in modulating hepatic phagocytic function by modifying liver-specific opsonic activity in serum. An increase in the physiological concentration of calcium will suppress and a decrease will enhance this opsonic activity.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number3
StatePublished - Dec 1 1990


  • Calcium
  • Kupffer cell
  • Liposome
  • Opsonin
  • Phagocytosis
  • Spleen macrophage

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology


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