Caffeine attenuates CNS oxygen toxicity in rats

Noemi Bitterman, Shlomit Schaal

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.

Original languageEnglish (US)
Pages (from-to)250-253
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Oct 23 1995


  • Adenosine receptor
  • Carbon dioxide
  • Hyperbaric oxygen
  • Hyperoxia
  • Methylxanthine
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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