Caffeine attenuates CNS oxygen toxicity in rats

Noemi Bitterman; Shlomit Schaal

doi:10.1016/0006-8993(95)00820-G

Caffeine attenuates CNS oxygen toxicity in rats

Noemi Bitterman, Shlomit Schaal

Houston Methodist

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO₂ at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.

Original language	English (US)
Pages (from-to)	250-253
Number of pages	4
Journal	Brain Research
Volume	696
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(95)00820-G
State	Published - Oct 23 1995

Keywords

Adenosine receptor
Carbon dioxide
Hyperbaric oxygen
Hyperoxia
Methylxanthine
Seizure

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(95)00820-G

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abstract = "We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.",

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AU - Bitterman, Noemi

AU - Schaal, Shlomit

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AB - We tested the effect of caffeine, on hyperoxia-induced seizures. Thirty-seven rats with chronic cortical electrodes were injected i.p. with caffeine (1.25, 2.5, and 10 mg/kg) or vehicle before exposure to 0.5 MPa oxygen and 17 rats to oxygen with 5% CO2 at 0.5 MPa. EEG monitoring and spectral analysis of EEG activity were carried out. Caffeine significantly prolonged the latent period to the onset of seizures (P < 0.05 in ANOVA), in a dose-related manner. Our results suggest that caffeine may be used in low doses for protection against hyperoxia-induced seizures.

KW - Adenosine receptor

KW - Carbon dioxide

KW - Hyperbaric oxygen

KW - Hyperoxia

KW - Methylxanthine

KW - Seizure

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Caffeine attenuates CNS oxygen toxicity in rats

Abstract

Keywords

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