TY - JOUR
T1 - CAD-CAM-generated hydroxyapatite scaffold to replace the mandibular condyle in sheep
T2 - Preliminary results
AU - Ciocca, Leonardo
AU - Donati, Davide
AU - Fantini, Massimiliano
AU - Landi, Elena
AU - Piattelli, Adriano
AU - Iezzi, Giovanna
AU - Tampieri, Anna
AU - Spadari, Alessandro
AU - Romagnoli, Noemi
AU - Scotti, Roberto
PY - 2013/8/1
Y1 - 2013/8/1
N2 - In this study, rapid CAD-CAM prototyping of pure hydroxyapatite to replace temporomandibular joint condyles was tested in sheep. Three adult animals were implanted with CAD-CAM-designed porous hydroxyapatite scaffolds as condyle substitutes. The desired scaffold shape was achieved by subtractive automated milling machining (block reduction). Custom-made surgical guides were created by direct metal laser sintering and were used to export the virtual planning of the bone cut lines into the surgical environment. Using the same technique, fixation plates were created and applied to the scaffold pre-operatively to firmly secure the condyles to the bone and to assure primary stability of the hydroxyapatite scaffolds during masticatory function. Four months post-surgery, the sheep were sacrificed. The hydroxyapatite scaffolds were explanted, and histological specimens were prepared. Different histological tissues penetrating the scaffold macropores, the sequence of bone remodeling, new apposition of bone and/or cartilage as a consequence of the different functional anatomic role, and osseointegration at the interface between the scaffold and bone were documented. This animal model was found to be appropriate for testing CAD-CAM customization and the biomechanical properties of porous, pure hydroxyapatite scaffolds used as joint prostheses.
AB - In this study, rapid CAD-CAM prototyping of pure hydroxyapatite to replace temporomandibular joint condyles was tested in sheep. Three adult animals were implanted with CAD-CAM-designed porous hydroxyapatite scaffolds as condyle substitutes. The desired scaffold shape was achieved by subtractive automated milling machining (block reduction). Custom-made surgical guides were created by direct metal laser sintering and were used to export the virtual planning of the bone cut lines into the surgical environment. Using the same technique, fixation plates were created and applied to the scaffold pre-operatively to firmly secure the condyles to the bone and to assure primary stability of the hydroxyapatite scaffolds during masticatory function. Four months post-surgery, the sheep were sacrificed. The hydroxyapatite scaffolds were explanted, and histological specimens were prepared. Different histological tissues penetrating the scaffold macropores, the sequence of bone remodeling, new apposition of bone and/or cartilage as a consequence of the different functional anatomic role, and osseointegration at the interface between the scaffold and bone were documented. This animal model was found to be appropriate for testing CAD-CAM customization and the biomechanical properties of porous, pure hydroxyapatite scaffolds used as joint prostheses.
KW - animal study
KW - CAD-CAM
KW - rapid prototyping
KW - Regenerative medicine
KW - scaffolding
UR - http://www.scopus.com/inward/record.url?scp=84881128830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881128830&partnerID=8YFLogxK
U2 - 10.1177/0885328212443296
DO - 10.1177/0885328212443296
M3 - Article
C2 - 22492196
AN - SCOPUS:84881128830
VL - 28
SP - 207
EP - 218
JO - Journal of Biomaterials Applications
JF - Journal of Biomaterials Applications
SN - 0885-3282
IS - 2
ER -