Ca-ATPase and bone cell mineralization

Joel Abramowitz, Wadi N. Suki

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The plasma membrane Ca-ATPases play an important role in the regulation of intracellular Ca2+ ion concentration by pumping Ca2+ out of the cell into the extracellular fluid at the expense of ATP. These pumps potentially play an important role in the delivery of Ca2+ during mineralization of hard tissues such as bone. The properties of the plasma membrane Ca2+ pump are compared with those of the sarco(endo)plasmic reticulum and the factors regulating pump function are presented. The different gene products for the plasma membrane Ca-ATPases are described as well as their known functional significance. Particular attention is paid to the plasma membrane Ca2+ pumps present in mineralizing tissues and evidence supporting a role for these pumps in the transcellular delivery of Ca2+ during the process of mineralization is also presented.

Original languageEnglish (US)
Pages (from-to)336-344
Number of pages9
JournalMineral and Electrolyte Metabolism
Volume22
Issue number5-6
StatePublished - Nov 1 1996

Keywords

  • bone
  • calcium transport
  • cartilage
  • dentin
  • enamel
  • mineralization
  • plasma membrane calcium pumps

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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