C. elegans as a model system for Parkinson disease

Pu Pu, Weidong Le

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Parkinson disease(PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra. Although investigation in mammalian animal models of PD has enhanced our understanding of PD, the complexity of the mammalian nervous system and our inability to visualize DA neurons in vivo restricts the advances in elucidating the molecular mechanisms of PD. Conservation between C. elegans and mammals in genomic, biosynthetic and metabolic pathways as well as the advantages of observing DA neurons morphology in vivo and the ease of transgenic and genetic manipulation make C. elegans an excellent model organism for PD.

Original languageEnglish (US)
Pages (from-to)124-128
Number of pages5
JournalNeuroscience Bulletin
Volume22
Issue number2
StatePublished - Mar 1 2006

Keywords

  • Caenorhabditis elegans (C. elegans)
  • Dopaminergic neuron
  • Parkinson disease

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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