Bronchiolar wall changes in sudden infant death syndrome: Morphometric study of a new observation

Abida K. Haque; Melodee G. Mancuso; James Hokanson; Nghia D. Nguyen; Myron M. Nichols

doi:10.3109/15513819109064790

Bronchiolar wall changes in sudden infant death syndrome: Morphometric study of a new observation

Abida K. Haque, Melodee G. Mancuso, James Hokanson, Nghia D. Nguyen, Myron M. Nichols

Academic Institute

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Sudden infant death syndrome (SIDS) infants have significantly thicker and more cellular bronchiolar walls than control infants of similar age. A morphometric study of 25 SIDS and 18 control infants was undertaken to measure the bronchiolar wall thickness using a Cue-2 image analysis system. A mathematical formula (relative index) was used to compare the thickness of bronchioles of varying diameter. Data analysis using a nested design two-way analysis of variance and covariance of the measured bronchioles showed a significant difference between the SIDS and control infants with a P value less than .001. Manual counting of the cells in the bronchiolar walls and data analysis using an unpaired two-tailed t test showed that the SIDS infants had a significantly greater number of cells than control infants (P < .01). Our preliminary results indicate that the cells in the bronchiolar wall are either peripheral nerve-derived (Schwann cells) or Langerhans cells. We postulate that these cells are increased in number in response to chronic hypoxia in SIDS infants.

Original language	English (US)
Pages (from-to)	551-568
Number of pages	18
Journal	Fetal and Pediatric Pathology
Volume	11
Issue number	4
DOIs	https://doi.org/10.3109/15513819109064790
State	Published - 1991

Keywords

Bronchioles
Computerized image analysis
Hypoxia
Infants
Morphometry
Sudden infant death syndrome

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Pathology and Forensic Medicine

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10.3109/15513819109064790

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title = "Bronchiolar wall changes in sudden infant death syndrome: Morphometric study of a new observation",

abstract = "Sudden infant death syndrome (SIDS) infants have significantly thicker and more cellular bronchiolar walls than control infants of similar age. A morphometric study of 25 SIDS and 18 control infants was undertaken to measure the bronchiolar wall thickness using a Cue-2 image analysis system. A mathematical formula (relative index) was used to compare the thickness of bronchioles of varying diameter. Data analysis using a nested design two-way analysis of variance and covariance of the measured bronchioles showed a significant difference between the SIDS and control infants with a P value less than .001. Manual counting of the cells in the bronchiolar walls and data analysis using an unpaired two-tailed t test showed that the SIDS infants had a significantly greater number of cells than control infants (P < .01). Our preliminary results indicate that the cells in the bronchiolar wall are either peripheral nerve-derived (Schwann cells) or Langerhans cells. We postulate that these cells are increased in number in response to chronic hypoxia in SIDS infants.",

keywords = "Bronchioles, Computerized image analysis, Hypoxia, Infants, Morphometry, Sudden infant death syndrome",

author = "Haque, {Abida K.} and Mancuso, {Melodee G.} and James Hokanson and Nguyen, {Nghia D.} and Nichols, {Myron M.}",

note = "Funding Information: This work was funded in part by a grant from the National Sudden Infant Death Syndrome Foundation. Address reprint requests to Abida K. Haque, M.D., Department of Pathology, University of Texas Medical Branch, Route G-47, Calveston, Texas 77550.",

year = "1991",

doi = "10.3109/15513819109064790",

language = "English (US)",

volume = "11",

pages = "551--568",

journal = "Fetal and Pediatric Pathology",

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T1 - Bronchiolar wall changes in sudden infant death syndrome

T2 - Morphometric study of a new observation

AU - Haque, Abida K.

AU - Mancuso, Melodee G.

AU - Hokanson, James

AU - Nguyen, Nghia D.

AU - Nichols, Myron M.

N1 - Funding Information: This work was funded in part by a grant from the National Sudden Infant Death Syndrome Foundation. Address reprint requests to Abida K. Haque, M.D., Department of Pathology, University of Texas Medical Branch, Route G-47, Calveston, Texas 77550.

PY - 1991

Y1 - 1991

N2 - Sudden infant death syndrome (SIDS) infants have significantly thicker and more cellular bronchiolar walls than control infants of similar age. A morphometric study of 25 SIDS and 18 control infants was undertaken to measure the bronchiolar wall thickness using a Cue-2 image analysis system. A mathematical formula (relative index) was used to compare the thickness of bronchioles of varying diameter. Data analysis using a nested design two-way analysis of variance and covariance of the measured bronchioles showed a significant difference between the SIDS and control infants with a P value less than .001. Manual counting of the cells in the bronchiolar walls and data analysis using an unpaired two-tailed t test showed that the SIDS infants had a significantly greater number of cells than control infants (P < .01). Our preliminary results indicate that the cells in the bronchiolar wall are either peripheral nerve-derived (Schwann cells) or Langerhans cells. We postulate that these cells are increased in number in response to chronic hypoxia in SIDS infants.

AB - Sudden infant death syndrome (SIDS) infants have significantly thicker and more cellular bronchiolar walls than control infants of similar age. A morphometric study of 25 SIDS and 18 control infants was undertaken to measure the bronchiolar wall thickness using a Cue-2 image analysis system. A mathematical formula (relative index) was used to compare the thickness of bronchioles of varying diameter. Data analysis using a nested design two-way analysis of variance and covariance of the measured bronchioles showed a significant difference between the SIDS and control infants with a P value less than .001. Manual counting of the cells in the bronchiolar walls and data analysis using an unpaired two-tailed t test showed that the SIDS infants had a significantly greater number of cells than control infants (P < .01). Our preliminary results indicate that the cells in the bronchiolar wall are either peripheral nerve-derived (Schwann cells) or Langerhans cells. We postulate that these cells are increased in number in response to chronic hypoxia in SIDS infants.

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KW - Morphometry

KW - Sudden infant death syndrome

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Bronchiolar wall changes in sudden infant death syndrome: Morphometric study of a new observation

Abstract

Keywords

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