Brominated radiopaque liposomes: Contrast agent for computed tomography of liver and spleen a preliminary report

Vicente J. Caride, Henry Dirk Sostman, Jeff Twickler, Harry Zacharis, Stelios C. Orphanoudakis, C. Carl Jaffe

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter). Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge, composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.

Original languageEnglish (US)
Pages (from-to)381-384
Number of pages4
JournalInvestigative Radiology
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1982

Keywords

  • Computed tomography
  • Liver and spleen enhancement
  • Radiopaque liposomes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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