Brominated radiopaque liposomes: Contrast agent for computed tomography of liver and spleen a preliminary report

Vicente J. Caride; Henry Dirk Sostman; Jeff Twickler; Harry Zacharis; Stelios C. Orphanoudakis; C. Carl Jaffe

doi:10.1097/00004424-198207000-00014

Brominated radiopaque liposomes: Contrast agent for computed tomography of liver and spleen a preliminary report

Vicente J. Caride, Henry Dirk Sostman, Jeff Twickler, Harry Zacharis, Stelios C. Orphanoudakis, C. Carl Jaffe

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter). Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge, composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.

Original language	English (US)
Pages (from-to)	381-384
Number of pages	4
Journal	Investigative Radiology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1097/00004424-198207000-00014
State	Published - Jan 1 1982

Keywords

Computed tomography
Liver and spleen enhancement
Radiopaque liposomes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/00004424-198207000-00014

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abstract = "Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter). Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge, composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.",

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T2 - Contrast agent for computed tomography of liver and spleen a preliminary report

AU - Caride, Vicente J.

AU - Sostman, Henry Dirk

AU - Twickler, Jeff

AU - Zacharis, Harry

AU - Orphanoudakis, Stelios C.

AU - Carl Jaffe, C.

PY - 1982/1/1

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N2 - Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter). Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge, composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.

AB - Contrast enhancement of liver and spleen in the dog was obtained after intravenous administration of brominated radioopaque liposomes (ROL) (1-5 micron in diameter). Computed tomographic (CT) numbers generated before and after 3 hours of ROL administration demonstrated an increase in hepatic attenuation. ROL are biodegradable lipid vesicles that can be subjected to further physicochemical modifications (size, charge, composition) that alter their biodistribution and pharmacokinetics. These changes can result in improved hepatosplenic contrast enhancement.

KW - Computed tomography

KW - Liver and spleen enhancement

KW - Radiopaque liposomes

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Brominated radiopaque liposomes: Contrast agent for computed tomography of liver and spleen a preliminary report

Abstract

Keywords

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