Brief electrical stimulation of cerebellar fastigial nucleus conditions long-lasting salvage from focal cerebral ischemia: Conditioned central neurogenic neuroprotection

Donald J. Reis, Keith Kobylarz, Seiji Yamamoto, Eugene V. Golanov

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The cerebellar fastigial nucleus (FN) was electrically stimulated for 1 h in anesthetized rats and the middle cerebral artery occluded at various times thereafter. Stimulation of the FN but not dentate nucleus reduced the volume of the focal infarction to 50%. Protection persisted for 10 but disappeared by 30 d. Intrinsic neuronal pathways which function to condition central neurogenic neuroprotection can protect the brain from ischemic injury by processes independent of cerebral blood flow.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalBrain Research
Volume780
Issue number1
DOIs
StatePublished - Jan 5 1998

Keywords

  • Conditioning
  • Electrical stimulation
  • Fastigial nucleus
  • Focal infarction
  • Middle cerebral artery occlusion
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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