Brief communication: Tumor suppression by Mycobacterium bovis (Strain BCG) enhanced by vitamin A

Monte S. Meltzer; Benjamin E. Cohen

doi:10.1093/jnci/53.2.585

Brief communication: Tumor suppression by Mycobacterium bovis (Strain BCG) enhanced by vitamin A

Monte S. Meltzer, Benjamin E. Cohen

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Abstract

Tumor suppression mediated by Mycobacterium bovis (strain BCG) was enhanced in vitamin A-treated mice. A significant decrease in tumor incidence was observed with a transplantable, syngeneic, 3-methylcholanthrene-induced sarcoma when tumor cells were mixed with 6×10⁴ colony-forming units of BCG and injected intradermally into vitamin A-treated animals. This level of tumor suppression required 100-fold higher concentrations of BCG in untreated animals. Vitamin A treatment without BCG had no effect on tumor incidence or growth.

Original language	English (US)
Pages (from-to)	585-587
Number of pages	3
Journal	Journal of the National Cancer Institute
Volume	53
Issue number	2
DOIs	https://doi.org/10.1093/jnci/53.2.585
State	Published - Aug 1974

ASJC Scopus subject areas

Oncology
Cancer Research

Divisions

Plastic and Reconstructive Surgery

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title = "Brief communication: Tumor suppression by Mycobacterium bovis (Strain BCG) enhanced by vitamin A",

abstract = "Tumor suppression mediated by Mycobacterium bovis (strain BCG) was enhanced in vitamin A-treated mice. A significant decrease in tumor incidence was observed with a transplantable, syngeneic, 3-methylcholanthrene-induced sarcoma when tumor cells were mixed with 6×104 colony-forming units of BCG and injected intradermally into vitamin A-treated animals. This level of tumor suppression required 100-fold higher concentrations of BCG in untreated animals. Vitamin A treatment without BCG had no effect on tumor incidence or growth.",

author = "Meltzer, \{Monte S.\} and Cohen, \{Benjamin E.\}",

year = "1974",

month = aug,

doi = "10.1093/jnci/53.2.585",

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journal = "Journal of the National Cancer Institute",

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AU - Meltzer, Monte S.

AU - Cohen, Benjamin E.

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AB - Tumor suppression mediated by Mycobacterium bovis (strain BCG) was enhanced in vitamin A-treated mice. A significant decrease in tumor incidence was observed with a transplantable, syngeneic, 3-methylcholanthrene-induced sarcoma when tumor cells were mixed with 6×104 colony-forming units of BCG and injected intradermally into vitamin A-treated animals. This level of tumor suppression required 100-fold higher concentrations of BCG in untreated animals. Vitamin A treatment without BCG had no effect on tumor incidence or growth.

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ER -

Brief communication: Tumor suppression by Mycobacterium bovis (Strain BCG) enhanced by vitamin A

Abstract

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