Breast Implant-associated Anaplastic Large Cell Lymphoma: A Prospective Series of 52 Patients

Sarah E. Tevis, Kelly K. Hunt, Roberto N. Miranda, Caitlin Lange, Chelsea C. Pinnix, Swaminathan Iyer, Charles E. Butler, Mark W. Clemens

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: We sought to evaluate patients at a single academic institution in a prospective manner to report patient presentation, clinical course, treatment, and outcomes in breast implant ALCL patients. Background: Breast implant-associated anaplastic large cell lymphoma (breast implant ALCL) is an uncommon T cell lymphoma, which is associated with textured surface breast implants. The disease has received increasing attention over the last 20 years. Previous retrospective studies have begun to outline the clinical course of breast implant ALCL. Methods: We prospectively followed women with cytologically proven breast implant ALCL from 2014 to 2019. Demographic, clinical, treatment, and outcome data were collected and descriptive statistics were performed on variables of interest. Results: We identified 52 women with pathologically confirmed breast implant ALCL. Implants were placed for augmentation in 61.5% of women and reconstruction in 36.5% of women. All of the 41 patients with known implant information had implants with textured surface. The majority of patients presented with delayed seroma (69.2%) and without systemic symptoms (86.5%). Most patients with staging information presented with Stage IA disease. Patient outcomes were excellent with 2 disease recurrence (3.8%) and all patients ultimately achieved complete remission. Conclusions: Further evaluation of the prospective and growing database of patientswith breast implantALCLwill further improve our understanding of the disease and its clinical course. Robust participation in the breast implant ALCL PROFILE registry will improve our knowledge of long-term outcomes after implant placement. Finally, increasing awareness for patients and providers will lead to earlier diagnosis and improved outcomes for patients.

Original languageEnglish (US)
Pages (from-to)E245-E249
JournalAnnals of surgery
Issue number1
StatePublished - Jan 1 2022


  • Breast augmentation
  • Breast implant associated anaplastic large cell lymphoma
  • Breast reconstruction
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Surgery


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