Breast Carcinoma with Choriocarcinomatous Features

Erika Resetkova, Aysegul Sahin, Alberto G. Ayala, Nour Sneige

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Although breast carcinomas have been shown to produce various ectopic substances, including human chorionic gonadotropin, it is rare to identify morphologic differentiation compatible with the hormone produced by a tumor. Presently, only eight cases of breast carcinoma with focal choriocarcinomatous differentiation have been reported in the literature. This article describes the pathologic findings, immunohistochemical profile, and clinical course in two additional cases of this unusual variant of breast carcinoma. In the first case, the tumor had morphologic features suggestive of medullary carcinoma, and the patient is doing well 12 months after presentation. In the second case, the tumor was locally advanced at presentation with histologic features consistent with metaplastic carcinoma having squamous, sarcomatoid, and choriocarcinomatous elements. The patient presented with extensive multifocal metastases 6 months after the initial presentation and is not responding well to standard or experimental treatment regimen. Immunostaining for the β subunit of human chorionic gonadotropin was localized mostly, but not entirely, to multinucleated syncytiotrophoblast-like giant cells within both tumors.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalAnnals of Diagnostic Pathology
Issue number2
StatePublished - Apr 2004


  • Breast cancer
  • Choriocarcinoma
  • HCG
  • Metaplastic carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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