Breast cancer stem cells

Dong Soon Choi, Roberto R. Rosato, Jenny C. Chang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer stem cells (CSCs) represent a heterogeneous subpopulation of cancer cells within tumors. CSCs divide asymmetrically to generate daughter cells that either have CSC characteristics including self-renewal, or differentiation potential to form neoplastic cells which constitute most of the tumor. These characteristics suggest that the cells may play an important role in tumor initiation, and development of chemo-resistance. These characteristics are evident in the ability of CSCs to seed new tumors upon transplantation in experimental animal models. In this chapter, we describe the evidence around the role of CSCs in breast cancer. A brief overview of the methods and markers used to identify these cells is also provided. More importantly, we present the data regarding the signaling pathways that are implicated in the aggressiveness associated with CSCs. Lastly, we discuss the strategies that can be used for targeting these pathways for therapeutic purposes.

Original languageEnglish (US)
Title of host publicationMolecular Pathology of Breast Cancer
PublisherSpringer International Publishing
Pages133-151
Number of pages19
ISBN (Electronic)9783319417615
ISBN (Print)9783319417592
DOIs
StatePublished - Jan 1 2016

Keywords

  • ALDH1
  • CD24
  • CD44
  • Chemo-resistance
  • Cscs

ASJC Scopus subject areas

  • Medicine(all)

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