TY - JOUR
T1 - Breakthroughs and Applications of Organ-on-a-Chip Technology
AU - Koyilot, Mufeeda C.
AU - Natarajan, Priyadarshini
AU - Hunt, Clayton R.
AU - Sivarajkumar, Sonish
AU - Roy, Romy
AU - Joglekar, Shreeram
AU - Pandita, Shruti
AU - Tong, Carl W.
AU - Marakkar, Shamsudheen
AU - Subramanian, Lakshminarayanan
AU - Yadav, Shalini S.
AU - Cherian, Anoop V.
AU - Pandita, Tej K.
AU - Shameer, Khader
AU - Yadav, Kamlesh K.
N1 - Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/2
Y1 - 2022/6/2
N2 - Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.
AB - Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous ad-vantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease mod-elling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.
KW - heart
KW - kidney
KW - liver
KW - lung
KW - organ-on-a-chip
KW - technology
KW - Artificial Intelligence
KW - Biocompatible Materials
KW - Lab-On-A-Chip Devices
KW - Microfluidics
KW - Tissue Engineering
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U2 - 10.3390/cells11111828
DO - 10.3390/cells11111828
M3 - Review article
C2 - 35681523
AN - SCOPUS:85131264242
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 11
M1 - 1828
ER -