Brain tumour stem cells

Angelo Vescovi, Rossella Galli, Brent A. Reynolds

Research output: Contribution to journalReview article

759 Scopus citations

Abstract

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)425-436
Number of pages12
JournalNature Reviews Cancer
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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