Brain Synapses: An in Vitro Model for the Study of Seizures

Antonio V. Escueta, Stanley H. Appel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Electrophysiological studies have recently emphasized abnormal synaptic function as an important factor in the generation of seizure discharges. To further delineate these abnormalities, synaptic terminals (synaptosomes) were isolated from brains of animals with seizures. After repeated electroconvulsions (a model used to study the effects of seizures), the level of potassium decreased while that of sodium increased within synaptic terminals because of an enhanced downhill movement of cations. In epileptogenic foci of freezing lesions (a model used to study epileptogenesis), K influx mediated by the Na-K pump was markedly impaired with synaptic terminals. Both pathologic processes in membrane function were corrected by diphenylhydantoin through its stimulation of the Na-K pump. In epileptogenic foci, diphenylhydantoin may also have a direct action on the synapse membrane, apart from its effects on the Na-K pump.

Original languageEnglish (US)
Pages (from-to)333-344
Number of pages12
JournalArchives of Internal Medicine
Volume129
Issue number2
DOIs
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Internal Medicine

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