Brain magnetic resonance imaging (MRI) in parkinsonian disorders

Oraporn Sitburana, William G. Ondo

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Magnetic resonance imaging (MRI) is increasingly integrated into neurological diagnostics. In addition to functional MRI, a large number of sequences (T1W, T2W, PD, T2*W gradient echo, diffusion-weighted imaging (DWI), and diffusion tensor imaging (DTI)), investigate CNS abnormalities. Objective quantification techniques (T1W voxel-based morphometry) can also discern subtle anatomical differences. Parkinsonian conditions such as Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and manganese-induced parkinsonism can clinically overlap, yet have very different prognoses and treatments. Relatively little radiographic interest has focused on movement disorders. Nevertheless in the past decade, a variety of findings, often subtle and routinely overlooked, have emerged to help the clinician differentiate these conditions. This review will summarize and discuss MRI findings in parkinsonian conditions. Most data concern either structural abnormalities or the imaging sequelae of abnormal iron deposition, common in some parkinsonian conditions.

Original languageEnglish (US)
Pages (from-to)165-174
Number of pages10
JournalParkinsonism and Related Disorders
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Iron
  • Magnetic resonance imaging
  • Manganese
  • Parkinsonian disorders

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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