Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease

Juha O. Rinne, V. Kaasinen, T. Järvenpää, K. Någren, A. Roivainen, M. Yu, V. Oikonen, T. Kurki

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Objective: Brain acetylcholinesterase activity was determined in healthy controls and in patients with mild cognitive impairment and early Alzheimer's disease. Methods: A specific acetylcholinesterase tracer, [methyl 11C]N-methyl-piperidyl-4-acetate ([11C]MP4A), and a three dimensional PET system with magnetic resonance coregistration were used for imaging. Results: There was a significant difference in the acetylcholinesterase activity in the hippocampus between the groups (p = 0.03), the mean (SD) acetylcholinesterase activity (k3 values, min-1) being 0.114 (0.036) in controls, 0.098 (0.023) in mild cognitive impairment, and 0.085 (0.022) in Alzheimer's disease. The mini-mental state examination score showed no significant relation with acetylcholinesterase activity in any brain area in the combined mild cognitive impairment/Alzheimer group. Conclusions: Hippocampal acetylcholinesterase activity is only slightly reduced in mild cognitive impairment and early Alzheimer's disease and so the value of in vivo acetylcholinesterase measurements in detecting the early Alzheimer process is limited.

Original languageEnglish (US)
Pages (from-to)113-115
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume74
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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