Brachial-ankle pulse wave velocity is associated with coronary calcium in young and middle-aged asymptomatic adults: The Kangbuk Samsung Health Study

Miguel Cainzos-Achirica, Sanjay Rampal, Yoosoo Chang, Seungho Ryu, Yiyi Zhang, Di Zhao, Juhee Cho, Yuni Choi, Roberto Pastor-Barriuso, So Yeon Lim, Jordi Bruguera, Roberto Elosua, Joao A.C. Lima, Hocheol Shin, Eliseo Guallar

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective: To evaluate the association between brachial-ankle pulse wave velocity (baPWV), a convenient, non-radiating, readily available measurement of arterial stiffness, and coronary artery calcium (CAC), a reliable marker of coronary atherosclerosis, in a large sample of young and middle-aged asymptomatic adults; and to assess the incremental value of baPWV for detecting prevalent CAC beyond traditional risk factors. Methods: Cross-sectional study of 15,185 asymptomatic Korean adults who voluntarily underwent a comprehensive health screening program including measurement of baPWV and CAC. BaPWV was measured using an oscillometric method with cuffs placed on both arms and ankles. CAC burden was assessed using a multi-detector CT scan and scored following Agatston's method. Results: The prevalence of CAC > 0 and CAC > 100 increased across baPWV quintiles. The multivariable-adjusted odds ratios (95% CI) for CAC > 0 comparing baPWV quintiles 2-5 versus quintile 1 were 1.06 (0.87-1.30), 1.24 (1.02-1.50), 1.39 (1.15-1.69) and 1.60 (1.31-1.96), respectively (P trend < 0.001). Similarly, the relative prevalence ratios for CAC > 100 were 1.30 (0.74-2.26), 1.59 (0.93-2.71), 1.74 (1.03-2.94) and 2.59 (1.54-4.36), respectively (P trend < 0.001). For CAC > 100, the area under the ROC curve for baPWV alone was 0.71 (0.68-0.74), and the addition of baPWV to traditional risk factors significantly improved the , and calibration of models for detecting prevalent CAC > 0 and CAC > 100. Conclusions: BaPWV was independently associated with the presence and severity of CAC in a large sample of young and middle-aged asymptomatic adults. BaPWV may be a valuable tool for identifying apparently low-risk individuals with increased burden of coronary atherosclerosis.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalAtherosclerosis
Volume241
Issue number2
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Keywords

  • Arterial stiffness
  • Atherosclerosis
  • Coronary artery calcium
  • Pulse wave velocity
  • Subclinical disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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