Botulinum toxin in urology: Evaluation using an evidence-based medicine approach

Christopher P. Smith, George T. Somogyi, Timothy B. Boone

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Clinical reports documenting the beneficial effects of botulinum toxin (BTX) to treat various lower urinary tract disorders of muscle spasticity (e.g. detrusor hyperreflexia, detrusor sphincter dyssynergia) have led to its expanded application in non-neurogenic conditions such as idiopathic detrusor overactivity, detrusor underactivity and benign prostatic hyperplasia (BPH). As greater numbers of investigators report their results utilizing this agent, it becomes more important that clinicians are able to synthesize and describe the findings of current clinical studies in a meaningful way. Evidence-based medicine is a platform on which investigations concerning a particular topic can be evaluated for their levels of scientific evidence, so that rational clinical recommendations can be formulated. This review article applies evidence-based practices to the use of BTX in common urologic conditions. Appreciating the benefits as well as limitations of currently available studies will hopefully drive the development of well-controlled, randomized studies of BTX, particularly in highly prevalent conditions such as idiopathic detrusor overactivity and BPH.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalNature Clinical Practice Urology
Volume1
Issue number1
DOIs
StatePublished - Nov 1 2004

Keywords

  • Bladder
  • Botulinum toxin
  • Evidence-based medicine
  • Prostate
  • Urethra

ASJC Scopus subject areas

  • Urology
  • Nephrology

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