Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies

G. A. Hale, Helen Heslop, L. C. Bowman, R. A. Rochester, C. H. Pui, Malcolm Brenner, R. A. Krance

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Twenty-one children who developed therapy-related acute myeloid leukemia after treatment for acute lymphoblastic leukemia received allogeneic bone marrow transplants between January 1990 and June 1997. All had previously received epipodophyllotoxin-containing regimens and 11 had cytogenetic abnormalities involving 11q23. Induction chemotherapy was given to 13 patients and eight patients went directly to BMT. Eleven received marrow from matched siblings, eight from matched unrelated donors and two from haploidentical family members. Conditioning regimens included cyclophosphamide (CY), cytarabine, and total body irradiation. Four patients are alive disease-free between 1118 and 1825 days post-BMT resulting in a 3-year DFS of 19%. Ten patients relapsed at a median of 150 days (range 30-664 days) post-BMT and all eventually died of disease. Seven patients died of regimen-related toxicity. The outlook for patients with therapy-related AML/MDS remains poor and more effective therapy is needed.

Original languageEnglish (US)
Pages (from-to)735-739
Number of pages5
JournalBone Marrow Transplantation
Volume24
Issue number7
DOIs
StatePublished - 1999

Keywords

  • Bone marrow transplantation
  • Children
  • Therapy-induced acute myeloid leukemia

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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