Bone Marrow Necrosis in Sickle Cell-Beta Thalassemia Patient Mimicking Thrombotic Thrombocytopenic Purpura

Charlotte F. Myers, Tina S. Ipe

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We describe a case of bone marrow necrosis (BMN) with subsequent fat embolism precipitated by high altitudes in a young healthy man with previously undiagnosed sickle cell-beta thalassemia. This case report adds to the growing literature on the complexity of diagnosing bone marrow necrosis given that the clinical and laboratory features mimic thrombotic thrombocytopenic purpura. This BMN with fat embolism syndrome (FES) is novel in that it was precipitated by high altitudes and the patient was treated successfully with a series of therapeutic plasma exchanges and red blood cell transfusions alone, without any adverse long-term complications to the patient.

Original languageEnglish (US)
Pages (from-to)670-673
Number of pages4
JournalAnnals of clinical and laboratory science
Volume48
Issue number5
StatePublished - Sep 1 2018

Keywords

  • bone marrow necrosis
  • fat embolism syndrome
  • HgbSβ+
  • multiorgan failure
  • TTP

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology

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