Body Weight Changes with β-Blocker Use: Results from GEMINI

Research output: Contribution to journalArticle

Franz H. Messerli, David S.H. Bell, Vivian Fonseca, Richard E. Katholi, Janet B. McGill, Robert A. Phillips, Philip Raskin, Jackson T. Wright, Sripal Bangalore, Fred K. Holdbrook, Mary Ann Lukas, Karen M. Anderson, George L. Bakris

Purpose: Patients with type 2 diabetes are commonly overweight, which can contribute to poor cardiovascular outcomes. β-blockers may promote weight gain, or hamper weight loss, and are a concern in high-risk patients. The current analysis of the Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial evaluates the effects of carvedilol and metoprolol tartrate on weight gain in patients with type 2 diabetes and hypertension. Methods: This prespecified secondary analysis of the GEMINI study (n=1106) evaluated change in body weight after 5 months. Results: Mean (±SE) baseline weights were 97.5 (±20.1) kg for carvedilol and 96.6 (±20.1) kg for metoprolol tartrate. Treatment difference (c vs m) in mean (±SE) weight change from baseline was -1.02 (±0.21) kg (95% confidence interval [CI], -1.43 to -0.60; P <.001). Patients taking metoprolol had a significant mean (±SE) weight gain of 1.19 (±0.16) kg (P <.001); patients taking carvedilol did not (0.17 [±0.19] kg; P =.36). Metoprolol tartrate-treated patients with body mass index (BMI) >30 kg/m2 had a statistically significant greater weight gain than comparable carvedilol-treated patients. Treatment differences (c vs m) in the obese (BMI >30 kg/m2) and morbidly obese groups (BMI >40 kg/m2) were -0.90 kg (95% CI, -1.5 to -0.3; P =.002) and -1.84 kg (95% CI, -2.9 to -0.8; P =.001), respectively. Pairwise correlation analyses revealed no significant associations between weight change and change in HbA1c, HOMA-IR, or blood pressure. Conclusions: Metoprolol tartrate was associated with increased weight gain compared to carvedilol; weight gain was most pronounced in subjects with hypertension and diabetes who were not taking insulin therapy.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalAmerican Journal of Medicine
Volume120
Issue number7
DOIs
StatePublished - Jul 1 2007

PMID: 17602935

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Body Weight Changes with β-Blocker Use : Results from GEMINI. / Messerli, Franz H.; Bell, David S.H.; Fonseca, Vivian; Katholi, Richard E.; McGill, Janet B.; Phillips, Robert A.; Raskin, Philip; Wright, Jackson T.; Bangalore, Sripal; Holdbrook, Fred K.; Lukas, Mary Ann; Anderson, Karen M.; Bakris, George L.

In: American Journal of Medicine, Vol. 120, No. 7, 01.07.2007, p. 610-615.

Research output: Contribution to journalArticle

Harvard

Messerli, FH, Bell, DSH, Fonseca, V, Katholi, RE, McGill, JB, Phillips, RA, Raskin, P, Wright, JT, Bangalore, S, Holdbrook, FK, Lukas, MA, Anderson, KM & Bakris, GL 2007, 'Body Weight Changes with β-Blocker Use: Results from GEMINI' American Journal of Medicine, vol. 120, no. 7, pp. 610-615. https://doi.org/10.1016/j.amjmed.2006.10.017

APA

Messerli, F. H., Bell, D. S. H., Fonseca, V., Katholi, R. E., McGill, J. B., Phillips, R. A., ... Bakris, G. L. (2007). Body Weight Changes with β-Blocker Use: Results from GEMINI. American Journal of Medicine, 120(7), 610-615. https://doi.org/10.1016/j.amjmed.2006.10.017

Vancouver

Messerli FH, Bell DSH, Fonseca V, Katholi RE, McGill JB, Phillips RA et al. Body Weight Changes with β-Blocker Use: Results from GEMINI. American Journal of Medicine. 2007 Jul 1;120(7):610-615. https://doi.org/10.1016/j.amjmed.2006.10.017

Author

Messerli, Franz H. ; Bell, David S.H. ; Fonseca, Vivian ; Katholi, Richard E. ; McGill, Janet B. ; Phillips, Robert A. ; Raskin, Philip ; Wright, Jackson T. ; Bangalore, Sripal ; Holdbrook, Fred K. ; Lukas, Mary Ann ; Anderson, Karen M. ; Bakris, George L. / Body Weight Changes with β-Blocker Use : Results from GEMINI. In: American Journal of Medicine. 2007 ; Vol. 120, No. 7. pp. 610-615.

BibTeX

@article{03ebdb68963f46ffbb4ba41409a9222f,
title = "Body Weight Changes with β-Blocker Use: Results from GEMINI",
abstract = "Purpose: Patients with type 2 diabetes are commonly overweight, which can contribute to poor cardiovascular outcomes. β-blockers may promote weight gain, or hamper weight loss, and are a concern in high-risk patients. The current analysis of the Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial evaluates the effects of carvedilol and metoprolol tartrate on weight gain in patients with type 2 diabetes and hypertension. Methods: This prespecified secondary analysis of the GEMINI study (n=1106) evaluated change in body weight after 5 months. Results: Mean (±SE) baseline weights were 97.5 (±20.1) kg for carvedilol and 96.6 (±20.1) kg for metoprolol tartrate. Treatment difference (c vs m) in mean (±SE) weight change from baseline was -1.02 (±0.21) kg (95{\%} confidence interval [CI], -1.43 to -0.60; P <.001). Patients taking metoprolol had a significant mean (±SE) weight gain of 1.19 (±0.16) kg (P <.001); patients taking carvedilol did not (0.17 [±0.19] kg; P =.36). Metoprolol tartrate-treated patients with body mass index (BMI) >30 kg/m2 had a statistically significant greater weight gain than comparable carvedilol-treated patients. Treatment differences (c vs m) in the obese (BMI >30 kg/m2) and morbidly obese groups (BMI >40 kg/m2) were -0.90 kg (95{\%} CI, -1.5 to -0.3; P =.002) and -1.84 kg (95{\%} CI, -2.9 to -0.8; P =.001), respectively. Pairwise correlation analyses revealed no significant associations between weight change and change in HbA1c, HOMA-IR, or blood pressure. Conclusions: Metoprolol tartrate was associated with increased weight gain compared to carvedilol; weight gain was most pronounced in subjects with hypertension and diabetes who were not taking insulin therapy.",
keywords = "Body Mass Index (BMI), Carvedilol, Diabetes, Hypertension, Metoprolol, Weight, β-blockers",
author = "Messerli, {Franz H.} and Bell, {David S.H.} and Vivian Fonseca and Katholi, {Richard E.} and McGill, {Janet B.} and Phillips, {Robert A.} and Philip Raskin and Wright, {Jackson T.} and Sripal Bangalore and Holdbrook, {Fred K.} and Lukas, {Mary Ann} and Anderson, {Karen M.} and Bakris, {George L.}",
year = "2007",
month = "7",
day = "1",
doi = "10.1016/j.amjmed.2006.10.017",
language = "English (US)",
volume = "120",
pages = "610--615",
journal = "American Journal of Medicine",
issn = "0002-9343",
number = "7",

}

RIS

TY - JOUR

T1 - Body Weight Changes with β-Blocker Use

T2 - American Journal of Medicine

AU - Messerli, Franz H.

AU - Bell, David S.H.

AU - Fonseca, Vivian

AU - Katholi, Richard E.

AU - McGill, Janet B.

AU - Phillips, Robert A.

AU - Raskin, Philip

AU - Wright, Jackson T.

AU - Bangalore, Sripal

AU - Holdbrook, Fred K.

AU - Lukas, Mary Ann

AU - Anderson, Karen M.

AU - Bakris, George L.

PY - 2007/7/1

Y1 - 2007/7/1

N2 - Purpose: Patients with type 2 diabetes are commonly overweight, which can contribute to poor cardiovascular outcomes. β-blockers may promote weight gain, or hamper weight loss, and are a concern in high-risk patients. The current analysis of the Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial evaluates the effects of carvedilol and metoprolol tartrate on weight gain in patients with type 2 diabetes and hypertension. Methods: This prespecified secondary analysis of the GEMINI study (n=1106) evaluated change in body weight after 5 months. Results: Mean (±SE) baseline weights were 97.5 (±20.1) kg for carvedilol and 96.6 (±20.1) kg for metoprolol tartrate. Treatment difference (c vs m) in mean (±SE) weight change from baseline was -1.02 (±0.21) kg (95% confidence interval [CI], -1.43 to -0.60; P <.001). Patients taking metoprolol had a significant mean (±SE) weight gain of 1.19 (±0.16) kg (P <.001); patients taking carvedilol did not (0.17 [±0.19] kg; P =.36). Metoprolol tartrate-treated patients with body mass index (BMI) >30 kg/m2 had a statistically significant greater weight gain than comparable carvedilol-treated patients. Treatment differences (c vs m) in the obese (BMI >30 kg/m2) and morbidly obese groups (BMI >40 kg/m2) were -0.90 kg (95% CI, -1.5 to -0.3; P =.002) and -1.84 kg (95% CI, -2.9 to -0.8; P =.001), respectively. Pairwise correlation analyses revealed no significant associations between weight change and change in HbA1c, HOMA-IR, or blood pressure. Conclusions: Metoprolol tartrate was associated with increased weight gain compared to carvedilol; weight gain was most pronounced in subjects with hypertension and diabetes who were not taking insulin therapy.

AB - Purpose: Patients with type 2 diabetes are commonly overweight, which can contribute to poor cardiovascular outcomes. β-blockers may promote weight gain, or hamper weight loss, and are a concern in high-risk patients. The current analysis of the Glycemic Effect in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial evaluates the effects of carvedilol and metoprolol tartrate on weight gain in patients with type 2 diabetes and hypertension. Methods: This prespecified secondary analysis of the GEMINI study (n=1106) evaluated change in body weight after 5 months. Results: Mean (±SE) baseline weights were 97.5 (±20.1) kg for carvedilol and 96.6 (±20.1) kg for metoprolol tartrate. Treatment difference (c vs m) in mean (±SE) weight change from baseline was -1.02 (±0.21) kg (95% confidence interval [CI], -1.43 to -0.60; P <.001). Patients taking metoprolol had a significant mean (±SE) weight gain of 1.19 (±0.16) kg (P <.001); patients taking carvedilol did not (0.17 [±0.19] kg; P =.36). Metoprolol tartrate-treated patients with body mass index (BMI) >30 kg/m2 had a statistically significant greater weight gain than comparable carvedilol-treated patients. Treatment differences (c vs m) in the obese (BMI >30 kg/m2) and morbidly obese groups (BMI >40 kg/m2) were -0.90 kg (95% CI, -1.5 to -0.3; P =.002) and -1.84 kg (95% CI, -2.9 to -0.8; P =.001), respectively. Pairwise correlation analyses revealed no significant associations between weight change and change in HbA1c, HOMA-IR, or blood pressure. Conclusions: Metoprolol tartrate was associated with increased weight gain compared to carvedilol; weight gain was most pronounced in subjects with hypertension and diabetes who were not taking insulin therapy.

KW - Body Mass Index (BMI)

KW - Carvedilol

KW - Diabetes

KW - Hypertension

KW - Metoprolol

KW - Weight

KW - β-blockers

UR - http://www.scopus.com/inward/record.url?scp=34250900379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250900379&partnerID=8YFLogxK

U2 - 10.1016/j.amjmed.2006.10.017

DO - 10.1016/j.amjmed.2006.10.017

M3 - Article

VL - 120

SP - 610

EP - 615

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 7

ER -

ID: 16847724