Blood levels of haloperidol and thioridazine during maintenance neuroleptic treatment of schizophrenic outpatients

Alla Shvartsburd, Cyrus Sajadi, Vona Morton, Mohsen Mirabi, Jack Gordon, Robert C. Smith

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Plasma and red blood cell levels of haloperidol, thioridazine, and thioridazine’s main metabolite mesoridazine were measured in schizophrenic out-patients during treatment with fixed doses of halo-peridol or thioridazine for several months. These drug levels were compared to those in schizo-phrenic inpatients treated with fixed doses of the same neuroleptics. There were large interpatient variations in plasma and red blood cell levels at a given dose for schizophrenic outpatients as well as for inpatients. The intrapatient day-to-day fluc-tuation was much greater in the outpatients. The mean coefficient of variation of thioridazine or mesoridazine levels was about two-fold higher in schizophrenic outpatients than in inpatients. Dif-ferences in blood sampling time or compliance in medication ingestion do not fully explain the issue. The factors accounting for the increased intrapa-tient variability of plasma levels of thioridazine, mesoridazine, and haloperidol in schizophrenic outpatients remain unclear.

Original languageEnglish (US)
Pages (from-to)194-198
Number of pages5
JournalJournal of Clinical Psychopharmacology
Volume4
Issue number4
DOIs
StatePublished - Aug 1984

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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