Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Shyny Koshy; Redwan Huq; Mark R. Tanner; Mustafa A. Atik; Paul C. Porter; Fatima S. Khan; Michael W. Pennington; Nicola A. Hanania; David Corry; Christine Beeton

doi:10.1074/jbc.M113.517037

Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Shyny Koshy, Redwan Huq, Mark R. Tanner, Mustafa A. Atik, Paul C. Porter, Fatima S. Khan, Michael W. Pennington, Nicola A. Hanania, David Corry, Christine Beeton

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58 Scopus citations

Abstract

Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

Original language	English (US)
Pages (from-to)	12623-12632
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M113.517037
State	Published - 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma",

abstract = "Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.",

author = "Shyny Koshy and Redwan Huq and Tanner, \{Mark R.\} and Atik, \{Mustafa A.\} and Porter, \{Paul C.\} and Khan, \{Fatima S.\} and Pennington, \{Michael W.\} and Hanania, \{Nicola A.\} and David Corry and Christine Beeton",

year = "2014",

doi = "10.1074/jbc.M113.517037",

language = "English (US)",

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pages = "12623--12632",

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T1 - Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

AU - Koshy, Shyny

AU - Huq, Redwan

AU - Tanner, Mark R.

AU - Atik, Mustafa A.

AU - Porter, Paul C.

AU - Khan, Fatima S.

AU - Pennington, Michael W.

AU - Hanania, Nicola A.

AU - Corry, David

AU - Beeton, Christine

PY - 2014

Y1 - 2014

N2 - Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

AB - Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

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SN - 0021-9258

VL - 289

SP - 12623

EP - 12632

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Abstract

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