Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Shyny Koshy; Redwan Huq; Mark R. Tanner; Mustafa A. Atik; Paul C. Porter; Fatima S. Khan; Michael W. Pennington; Nicola A. Hanania; David Corry; Christine Beeton

doi:10.1074/jbc.M113.517037

Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Shyny Koshy, Redwan Huq, Mark R. Tanner, Mustafa A. Atik, Paul C. Porter, Fatima S. Khan, Michael W. Pennington, Nicola A. Hanania, David Corry, Christine Beeton

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

Original language	English (US)
Pages (from-to)	12623-12632
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	289
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M113.517037
State	Published - 2014

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M113.517037

Cite this

@article{3e0651842f9540ec9b055d3a7e7bdc67,

title = "Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma",

abstract = "Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.",

author = "Shyny Koshy and Redwan Huq and Tanner, {Mark R.} and Atik, {Mustafa A.} and Porter, {Paul C.} and Khan, {Fatima S.} and Pennington, {Michael W.} and Hanania, {Nicola A.} and David Corry and Christine Beeton",

year = "2014",

doi = "10.1074/jbc.M113.517037",

language = "English (US)",

volume = "289",

pages = "12623--12632",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "18",

}

TY - JOUR

T1 - Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

AU - Koshy, Shyny

AU - Huq, Redwan

AU - Tanner, Mark R.

AU - Atik, Mustafa A.

AU - Porter, Paul C.

AU - Khan, Fatima S.

AU - Pennington, Michael W.

AU - Hanania, Nicola A.

AU - Corry, David

AU - Beeton, Christine

PY - 2014

Y1 - 2014

N2 - Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

AB - Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

UR - http://www.scopus.com/inward/record.url?scp=84899748553&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899748553&partnerID=8YFLogxK

U2 - 10.1074/jbc.M113.517037

DO - 10.1074/jbc.M113.517037

M3 - Article

C2 - 24644290

AN - SCOPUS:84899748553

SN - 0021-9258

VL - 289

SP - 12623

EP - 12632

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this