Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Shyny Koshy, Redwan Huq, Mark R. Tanner, Mustafa A. Atik, Paul C. Porter, Fatima S. Khan, Michael W. Pennington, Nicola A. Hanania, David Corry, Christine Beeton

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma.

Original languageEnglish (US)
Pages (from-to)12623-12632
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number18
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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