BK virus in solid organ transplant recipients: An emerging syndrome

Eleftherios Mylonakis, Nelson Goes, Robert H. Rubin, Anthony B. Cosimi, Robert B. Colvin, Jay A. Fishman

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

BK virus is a human polyomavirus associated with a range of clinical presentations from asymptomatic viruria with pyuria to ureteral ulceration with ureteral stenosis in renal transplant patients or hemorrhagic cystitis in bone marrow transplant recipients. Infection of renal allografts has been associated with diminished graft function in some individuals. Fortunately, however, the majority of patients with BK virus infections are asymptomatic. The type, duration, and intensity of immunosuppression are major contributors to susceptibility to the activation of BK virus infection. Histopathology is required for the demonstration of renal parenchymal involvement; urine cytology and viral polymerase chain reaction methods are useful adjunctive diagnostic tools. Current, treatment of immunosuppressed patients with polyomavirus viruria is largely supportive and directed toward minimizing immunosuppression. Improved diagnostic tools and antiviral therapies are needed for polyomavirus infections.

Original languageEnglish (US)
Pages (from-to)1587-1592
Number of pages6
JournalTransplantation
Volume72
Issue number10
DOIs
StatePublished - Nov 27 2001

ASJC Scopus subject areas

  • Transplantation

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