Bisursodeoxycholate(ethylenediamine)platinum(ii): A new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Martín Pérez-Andrés; Juan J. Benito; Emilio Rodríguez-Fernández; Bruna Corradetti; Daniel Primo; Juan L. Manzano; Alberto Orfao; Julio J. Criado

doi:10.1039/b807965j

Bisursodeoxycholate(ethylenediamine)platinum(ii): A new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Martín Pérez-Andrés, Juan J. Benito, Emilio Rodríguez-Fernández, Bruna Corradetti, Daniel Primo, Juan L. Manzano, Alberto Orfao, Julio J. Criado

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Abstract

The present paper describes for the first time an intrinsic fluorescent square-planar platinum(ii) complex carrying two ursodeoxycholate ligands ([Pt(UDC)₂(en)], where UDC^- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl ₂(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.

Original language	English (US)
Pages (from-to)	6159-6164
Number of pages	6
Journal	Dalton Transactions
Issue number	44
DOIs	https://doi.org/10.1039/b807965j
State	Published - 2008

ASJC Scopus subject areas

Inorganic Chemistry

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Pérez-Andrés, M., Benito, J. J., Rodríguez-Fernández, E., Corradetti, B., Primo, D., Manzano, J. L., Orfao, A., & Criado, J. J. (2008). Bisursodeoxycholate(ethylenediamine)platinum(ii): A new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines. Dalton Transactions, (44), 6159-6164. https://doi.org/10.1039/b807965j

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abstract = "The present paper describes for the first time an intrinsic fluorescent square-planar platinum(ii) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl 2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.",

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AU - Pérez-Andrés, Martín

AU - Benito, Juan J.

AU - Rodríguez-Fernández, Emilio

AU - Corradetti, Bruna

AU - Primo, Daniel

AU - Manzano, Juan L.

AU - Orfao, Alberto

AU - Criado, Julio J.

PY - 2008

Y1 - 2008

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AB - The present paper describes for the first time an intrinsic fluorescent square-planar platinum(ii) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl 2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.

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Bisursodeoxycholate(ethylenediamine)platinum(ii): A new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Abstract

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