Bisursodeoxycholate(ethylenediamine)platinum(ii): A new autofluorescent compound. Cytotoxic activity and cell cycle analysis in ovarian and hematological cell lines

Martín Pérez-Andrés, Juan J. Benito, Emilio Rodríguez-Fernández, Bruna Corradetti, Daniel Primo, Juan L. Manzano, Alberto Orfao, Julio J. Criado

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The present paper describes for the first time an intrinsic fluorescent square-planar platinum(ii) complex carrying two ursodeoxycholate ligands ([Pt(UDC)2(en)], where UDC- = ursodeoxycholate), that emits at room temperature once free in solution. Kinetic studies were carried out in aqueous solution and in the presence of different NaCl concentrations: 4 mM (similar to cytoplasmic concentration) and 150 mM (similar to plasmatic concentration). This novel compound was synthesized from a [PtCl 2(en)] complex and shows increased cytotoxic activity against both resting and cycling HeLa cells, with no toxicity for cell lines derived from neoplastic haematopoietic cells.

Original languageEnglish (US)
Pages (from-to)6159-6164
Number of pages6
JournalDalton Transactions
Issue number44
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Inorganic Chemistry

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