BioXyce: An engineering platform for the study of cellular systems

E. E. May, R. L. Schiek

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Researchers use constructs from the field of electrical engineering for the modelling and analysis of biological systems, but few exploit parallels between electrical and biological circuits for simulation purposes. The authors discuss the development of BioXyce, a circuit-based biological simulation platform that uses Xyce™, a large-scale electrical circuit simulator, as its simulation engine. BioXyce is capable of simulating whole-cell and multicellular systems. Simulation results for the central metabolism in Escherichia coli K12 and cellular differentiation in Drosophila sp. are presented.

Original languageEnglish (US)
Pages (from-to)77-89
Number of pages13
JournalIET Systems Biology
Volume3
Issue number2
DOIs
StatePublished - 2009

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Molecular Biology
  • Genetics
  • Cell Biology

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