Biosynthesis op 16α-hydroxyprogesterone by human fetal liver microsomes

B. P. Lisboa; J. Å Gustafsson

doi:10.1016/0039-128X(68)90042-1

Biosynthesis op 16α-hydroxyprogesterone by human fetal liver microsomes

B. P. Lisboa, J. Å Gustafsson

Houston Methodist

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

16α-Hydroxyprogesterone has been isolated and characterized after incubation of 4-[¹⁴C]-progesterone with 105,000 g microsomes of human fetal liver at midpregnancy. The identity of 16α-hydroxyprogesterone was proved by crystallizations to constant specific activity and by its behavior on thin-layer chromatography and gas-liquid chromatography as well as by gas chromatography-mass spectrometry.

Original language	English (US)
Pages (from-to)	249-260
Number of pages	12
Journal	Steroids
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0039-128X(68)90042-1
State	Published - Aug 1968

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/0039-128X(68)90042-1

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title = "Biosynthesis op 16α-hydroxyprogesterone by human fetal liver microsomes",

abstract = "16α-Hydroxyprogesterone has been isolated and characterized after incubation of 4-[14C]-progesterone with 105,000 g microsomes of human fetal liver at midpregnancy. The identity of 16α-hydroxyprogesterone was proved by crystallizations to constant specific activity and by its behavior on thin-layer chromatography and gas-liquid chromatography as well as by gas chromatography-mass spectrometry.",

author = "Lisboa, \{B. P.\} and Gustafsson, \{J. {\AA}\}",

note = "Funding Information: This investigation was supported by Research Grants K68-13X-2476-01 (to B.L.) and 13X-219 (to Dr. J. Sjiivall) of the Swedish Medical Research Council. The authors are indebted to {"}Stiftelsen Bengt Lundqvists Minne 'I for a scholarship awarded to one of us (J.-ii. G.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1968",

month = aug,

doi = "10.1016/0039-128X(68)90042-1",

language = "English (US)",

volume = "12",

pages = "249--260",

journal = "Steroids",

issn = "0039-128X",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Biosynthesis op 16α-hydroxyprogesterone by human fetal liver microsomes

AU - Lisboa, B. P.

AU - Gustafsson, J. Å

N1 - Funding Information: This investigation was supported by Research Grants K68-13X-2476-01 (to B.L.) and 13X-219 (to Dr. J. Sjiivall) of the Swedish Medical Research Council. The authors are indebted to "Stiftelsen Bengt Lundqvists Minne 'I for a scholarship awarded to one of us (J.-ii. G.). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1968/8

Y1 - 1968/8

N2 - 16α-Hydroxyprogesterone has been isolated and characterized after incubation of 4-[14C]-progesterone with 105,000 g microsomes of human fetal liver at midpregnancy. The identity of 16α-hydroxyprogesterone was proved by crystallizations to constant specific activity and by its behavior on thin-layer chromatography and gas-liquid chromatography as well as by gas chromatography-mass spectrometry.

AB - 16α-Hydroxyprogesterone has been isolated and characterized after incubation of 4-[14C]-progesterone with 105,000 g microsomes of human fetal liver at midpregnancy. The identity of 16α-hydroxyprogesterone was proved by crystallizations to constant specific activity and by its behavior on thin-layer chromatography and gas-liquid chromatography as well as by gas chromatography-mass spectrometry.

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U2 - 10.1016/0039-128X(68)90042-1

DO - 10.1016/0039-128X(68)90042-1

M3 - Article

C2 - 5691877

AN - SCOPUS:0014323020

SN - 0039-128X

VL - 12

SP - 249

EP - 260

JO - Steroids

JF - Steroids

IS - 2

ER -

Biosynthesis op 16α-hydroxyprogesterone by human fetal liver microsomes

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