TY - JOUR
T1 - Biosynthesis of Two New Steroids in the Human Foetal Liver, 1 β‐ and 2β‐Hydroxytestosterone
AU - Lisboa, B. P.
AU - Gustafsson, J.
PY - 1968/11
Y1 - 1968/11
N2 - Two new C19‐steroids with a 3‐oxo‐Δ4‐structure have been isolated and identified after incubation of testosterone with 105,000 × g microsomes of human foetal liver. These two ultraviolet positive metabolites were isolated by ascending one‐dimensional thin‐layer chromatography. The isolated compounds were identified as 1β‐ and 2β‐hydroxytestosterone by means of gas chromatography‐mass spectrometry. They were formed in approximately the same amount, each one representing about 15 % of the amount of 6β‐hydroxytestosterone formed.
AB - Two new C19‐steroids with a 3‐oxo‐Δ4‐structure have been isolated and identified after incubation of testosterone with 105,000 × g microsomes of human foetal liver. These two ultraviolet positive metabolites were isolated by ascending one‐dimensional thin‐layer chromatography. The isolated compounds were identified as 1β‐ and 2β‐hydroxytestosterone by means of gas chromatography‐mass spectrometry. They were formed in approximately the same amount, each one representing about 15 % of the amount of 6β‐hydroxytestosterone formed.
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U2 - 10.1111/j.1432-1033.1968.tb00463.x
DO - 10.1111/j.1432-1033.1968.tb00463.x
M3 - Article
C2 - 5749871
AN - SCOPUS:0014350716
VL - 6
SP - 419
EP - 424
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
SN - 0014-2956
IS - 3
ER -