Biosynthesis of Two New Steroids in the Human Foetal Liver, 1 β‐ and 2β‐Hydroxytestosterone

B. P. Lisboa, J. Gustafsson

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Two new C19‐steroids with a 3‐oxo‐Δ4‐structure have been isolated and identified after incubation of testosterone with 105,000 × g microsomes of human foetal liver. These two ultraviolet positive metabolites were isolated by ascending one‐dimensional thin‐layer chromatography. The isolated compounds were identified as 1β‐ and 2β‐hydroxytestosterone by means of gas chromatography‐mass spectrometry. They were formed in approximately the same amount, each one representing about 15 % of the amount of 6β‐hydroxytestosterone formed.

Original languageEnglish (US)
Pages (from-to)419-424
Number of pages6
JournalEuropean Journal of Biochemistry
Volume6
Issue number3
DOIs
StatePublished - Nov 1968

ASJC Scopus subject areas

  • Biochemistry

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