Biosynthesis of 6β‐ and 6α‐Hydroxyprogesterone in the Human Foetal Liver

B. P. Lisboa, J. Gustafsson

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

After incubation of progesterone with 105000 Xg microsomes of human foetal liver two C21O3 steroids were isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromato‐graphy‐mass spectrometry analysis showed that the compounds were identical with 6β‐ and 6α‐hydroxyprogesterone. The significance of this finding in relation to earlier reports of 6‐hy‐droxylated C21 steroids in human pregnancy urine is discussed.

Original languageEnglish (US)
Pages (from-to)503-506
Number of pages4
JournalEuropean Journal of Biochemistry
Volume9
Issue number4
DOIs
StatePublished - Jul 1969

ASJC Scopus subject areas

  • Biochemistry

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