Biosynthesis of 18‐Hydroxytestosterone in the Human Foetal Liver

B. P. Lisboa, Jan-Ake Gustafsson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

After incubation of testosterone with 105 000 X g microsomes of human foetal liver, a C19 steroid with a 3‐oxo‐Δ4‐structure was isolated by ascending one‐dimensional thin‐layer chromatography. Gas chromatography‐mass spectrometry revealed that the compound was identical with 18‐hydroxytestosterone. The significance of this finding in relation to earlier reports of 18‐hydroxylated steroids in human urine is discussed.

Original languageEnglish (US)
Pages (from-to)402-405
Number of pages4
JournalEuropean Journal of Biochemistry
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1969

ASJC Scopus subject areas

  • Biochemistry

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