Biopharmaceutics and therapeutic potential of engineered nanomaterials

Xing Jie Liang, Chunying Chen, Yuliang Zhao, Lee Jia, Paul C. Wang

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations

Abstract

Engineered nanomaterials are at the leading edge of the rapidly developing nanosciences and are founding an important class of new materials with specific physicochemical properties different from bulk materials with the same compositions. The potential for nanomaterials is rapidly expanding with novel applications constantly being explored in different areas. The unique size-dependent properties of nanomaterials make them very attractive for pharmaceutical applications. Investigations of physical, chemical and biological properties of engineered nanomaterials have yielded valuable information. Cytotoxic effects of certain engineered nanomaterials towards malignant cells form the basis for one aspect of nanomedicine. It is inferred that size, three dimensional shape, hydrophobicity and electronic configurations make them an appealing subject in medicinal chemistry. Their unique structure coupled with immense scope for derivatization forms a base for exciting developments in therapeutics. This review article addresses the fate of absorption, distribution, metabolism and excretion (ADME) of engineered nanoparticles in vitro and in vivo. It updates the distinctive methodology used for studying the biopharmaceutics of nanoparticles. This review addresses the future potential and safety concerns and genotoxicity of nanoparticle formulations in general. It particularly emphasizes the effects of nanoparticles on metabolic enzymes as well as the parenteral or inhalation administration routes of nanoparticle formulations. This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well.

Original languageEnglish (US)
Pages (from-to)697-709
Number of pages13
JournalCurrent Drug Metabolism
Volume9
Issue number8
DOIs
StatePublished - 2008

Keywords

  • Carbon nanotube
  • Engineered nanomaterials
  • Fullerenol
  • Magnetic nanoparticles
  • Metabolism
  • Nanomedicine
  • Silica dioxide (SiO2)
  • Titanium dioxide (TiO2)

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry

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