Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials

Francesca Taraballi, Manuela Sushnitha, Christopher Tsao, Guillermo Bauza, Chiara Liverani, Aaron Shi, Ennio Tasciotti

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.

Original languageEnglish (US)
Article number1800490
JournalAdvanced Healthcare Materials
Volume7
Issue number17
DOIs
StatePublished - Sep 5 2018

Keywords

  • foreign body reactions
  • immune tuning materials
  • implantable devices
  • inflammation
  • materials functionalization

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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