Biomimetic small exosome with outstanding surgical applications for rapid large-scale wound healing and functional sweat gland restoration

Huating Chen, Yawei Liu, Yiqiong Liu, Shuaifei Ji, Jiangbing Xiang, Yan Li, Laixian Zhou, Huanhuan Gao, Zihui Deng, Binghui Li, Sujing Sun, Shaoyuan Cui, Gongchi Li, Wei Sheng, Huiling Liu, Chunying Chen, Yuliang Zhao, Hongjie Zhang, Kai Liu, Xiaobing FuXiaoyan Sun

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The realization of coordinated infiltration of dermal and epidermal cell types, and the rapid deposition of extracellular matrix are the prerequisites for improved healing quality of large skin defects. However, presently used materials are limited for wound healing due to the inherent poor histocompatibility, low permeability, poor mechanical property and cytotoxicity. It is challenging to develop new therapeutic agents that enable timely and efficient wound healing and meanwhile there are minimal side effects to avoid chronic wounds, wound adhesions, and large scarring. Herein, we fabricated biomimetic exosomes (EMs) that enriched transforming growth factor β1 (TGF-β1) for the rapid healing of large-scale cutaneous wounds. The EM encapsulation allowed well-managed dosing of the TGF-β1 to effectively promote the wound healing process by endowing epidermal keratinocytes with a migratory feature, enhancing their stem cell properties, and resulting in accelerated in vivo wound re-epithelization. Specifically, the EMs could fast restore the function of sweat glands in a thermally injured mice model. Our work provides a promising strategy for improving the healing speed and healing quality for patients with large wounds.

Original languageEnglish (US)
Article number101531
JournalNano Today
Volume45
DOIs
StatePublished - Aug 2022

Keywords

  • Biomimetic materials
  • Exosome
  • Skin regeneration
  • Sweat glands
  • Wound healing

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Fingerprint

Dive into the research topics of 'Biomimetic small exosome with outstanding surgical applications for rapid large-scale wound healing and functional sweat gland restoration'. Together they form a unique fingerprint.

Cite this